Fig. 1 | Oncogene

Fig. 1

From: The interaction of Lin28A/Rho associated coiled-coil containing protein kinase2 accelerates the malignancy of ovarian cancer

Fig. 1

Lin28A accelerates the malignancy of ovarian cancer by promoting invasion and inhibiting cell apoptosis. a The effects of Lin28A on cell survival through CCK-8 analysis. *P < 0.05, ***P < 0.001. b Representative flow cytometry plots of Lin28A on cell apoptosis with Annexin V-EGFP and PI co-staining and statistical analysis. c Western blotting analysis of the levels of Lin28A and caspases (total and cleaved PARP, Caspase-9, −3 and −7). Actin acts as an internal reference. d The role of Lin28A in the invasion and metastasis of A2780 and PA-1 cells detected by transwell assay. Statistical analysis of invading cells. ***P < 0.001. Scale bars, 500 μm. e The effect of Lin28A on the levels of EMT-related molecules (Vimentin, Snail, Slug, N-cadherin, and β-catenin) and inhibitory molecule (ZO-1) examined by western blotting analysis

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