Fig. 2
NMH inhibits ROS production by Gr1+ cells from M-KrasG12D mice. a Two-hundred thousand Gr1+ cells from the spleen of M-KrasG12D mice were stimulated with WKYMVm (5×10−7M) in the presence or absence of NMH at indicated concentrations. Superoxide anion production was measured continuously during 12 min by chemiluminescence and is displayed as area under the curve (AUC) (n = 3 for each concentration). b Superoxide production from Gr1+ cells from the spleens of M-KrasG12D mice in response to stimulation with WKYMVm (5×10−7 M) in the presence or absence of NMH (100 µM) and the H2R antagonist ranitidine (RAN; 100 µM) (n = 4 for each group, t test). *p < 0.05, **p < 0.01, ***p < 0.001
