Table 1 Results of limiting dilution assay of MTHFD2 knocked down H322 cells in vitro

From: Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2

 

Cells (per well)

Tumor-initiating cell frequency estimate

Probability

 

13

25

50

100

  

NCT

0/10

3/10

3/10

4/10

1/154

 

shMTHFD2 #53

0/10

0/10

0/10

2/10

1/887

0.0082**

  1. NCT negative controls
  2. **p < 0.01
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