Table 2 Results of limiting dilution assay of MTHFD2 knocked down H322 cells in vivo

From: Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2

 

Cells (per well)

Tumor-initiating cell frequency estimate

Probability

 

102

103

104

105

  

NCT

0/6

0/6

2/6

6/6

1/2.4 × 104

 

shMTHFD2 #53

0/6

0/6

0/6

2/6

1/2.8 × 105

0.00137**

  1. NCT negative controls
  2. **p < 0.01
Back to article page