Fig. 4
From: Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma
Analysis of cell cycle distribution and DNA damage in neuroblastoma cell lines. a Quarfloxin and CX-5461 induce G2/M-arrest in TP53-mutated neuroblastoma cell lines. Flow cytometry analysis of cell cycle distribution in neuroblastoma cell lines BE(2)-C and SK-N-AS after 24 h treatment with 150 nM quarfloxin or 230 nM CX-5461. The data represent the mean percentage and SD of cells in G1, S, and G2/M phases from two individual experiments, each performed with two biological replicates. b Quarfloxin and CX-5461 induce DNA damage in neuroblastoma cell lines. Representative western blot of DNA damage marker γ-H2A.X in neuroblastoma cell lines exposed to 150 nM quarfloxin or 230 nM CX-5461 for 24 h
