Table 1 Half-maximal inhibitory concentration (IC50 values) from neuroblastoma cell lines treated with quarfloxin and CX-5461
From: Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma
Cell line | MYCN status | TP53 status | IC50 (nM)±SD | |
|---|---|---|---|---|
Quarfloxin | CX-5461 | |||
IMR-32 | Amp. | Wt | 5.0 ± 2.2 | 7.6 ± 0.21 |
CHP-134 | Amp. | Wt | 23.0 ± 14.7 | 40.1 ± 13.9 |
CHLA-15 | Non-amp. | Wt | 54.0 ± 3.7 | 25.8 ± 2.2 |
BE(2)-C | Amp. | Mut | 84.3 ± 5.0 | 106.9 ± 2.4 |
Kelly | Amp. | Mut | 150.1 ± 33.7 | 275.6 ± 29.7 |
SK-N-AS | Non-amp. | Mut | 965.2 ± 122.8 | 747.5 ± 65.8 |
SK-N-FI | Non-amp. | Mut | 967.6 ± 178.8 | 618.3 ± 99.1 |
SHEP-TET21N -dox | Exogenous, high MycN | Wt | 20.2 ± 0.03 | 14.4 ± 2.8 |
SHEP-TET21N + dox | Exogenous, low MycN | Wt | 357.2 ± 151.5 | 311.8 ± 9.1 |
