Fig. 7 | Oncogene

Fig. 7

From: Dynamic role of the codon 72 p53 single-nucleotide polymorphism in mammary tumorigenesis in a humanized mouse model

Fig. 7

Enhanced binding of R72 to promoters of cell cycle arrest and inflammation genes. Location of p53 response elements (REs) in the distal promoters of A. p21, B. Tnfα, and C. Ccl2 genes, relative to exon 1 (denoted as + 1). Comparisons are of mammary gland extracts from age-matched E-P72 and E-R72 mice. ChIP analysis of p53 binding to REs in the promoters of D. p21, E. Tnfα, and F. Ccl2 genes. All values were standardized to the mean of E-P72 samples, and reported as mean ± SEM (n = 3, *p < 0.05)

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