Fig. 3
Rival oncogene upregulates SPRY4 expression in growth suppressive melanoma cells. a The overall workflow and heat map results of microarray analysis of mRNA isolated from three melanoma cell lines as indicated. log2-fold differences as obtained by [log2(+Dox/oncogene) − log2(no Dox/oncogene)] − [log2(+Dox/vector) − log2(no Dox/vector)]. b DAVID enrichment scores (ES) for set of all genes that were significantly increased or decreased by at least twofold among antagonistic; SK-MEL-119NRAS* + iBRAF*, GMELBRAF* + iNRAS* and neutral; A375BRAF* + iNRAS* cell lines. c DAVID enrichment of growth suppressive overlapping significantly up- and downregulated (=2 folds) genes in SK-MEL-119NRAS* + iBRAF*, GMELBRAF* + iNRAS* cell lines but not A375. d SPRY4 transcripts were among the most upregulated ones in both SK-MEL-119NRAS* and GmelBRAF*, but not A375BRAF* cell lines
