Fig. 8
From: Lineage-specific control of TFIIH by MITF determines transcriptional homeostasis and DNA repair
Model of TFIIH-CAK regulation by MITF and c-MYC. In the melanocytic lineage, the microphthalmia-associated transcription factor (MITF) determines transcriptional homeostasis and genomic integrity through regulation of the transcription factor II H (TFIIH) and the CDK-activating kinase (CAK) complex. (I) MITF controls general transcription and UVR-induced nucleotide excision repair by targeting the transcription initiation complex through direct transactivation of GTF2H1 as a core element of TFIIH. (II) The melanocyte master regulator MITF and its structural homolog c-MYC control the expression of CDK7, the catalytic subunit of CAK complex, which has a dual role in transcription and cell cycle activities. (III) MITF controls MYC activities by transactivation of fuse binding protein (FUBP2) involved in pulse regulation of MYC. In addition, MYC is likely affected by MITF-dependent effects on proliferation
