Fig. 4
From: PKNOX2 suppresses gastric cancer through the transcriptional activation of IGFBP5 and p53
PKNOX2 suppressed gastric cancer cell migration/invasion in vitro. a PKNOX2 overexpression suppressed GC wound closure in AGS and MKN45 cells (AGS, P < 0.05; MKN45, P < 0.01), whilst (b) PKNOX2 knockdown in GES1 cells had an opposite effect (shPKNOX2-1, P = 0.0141; shPKNOX2-2, P < 0.01). c PKNOX2 overexpression in AGS cells suppressed cell invasion(P < 0.001); while silencing of PKNOX2 in GES1 cells promoted cell invasion(both P < 0.01). d PKNOX2 negatively regulated EMT, indicated by increased expression of E-cadherin and decreased expression of Vimentin and Slug. *P < 0.05; **P < 0.001; ***P < 0.0001)
