Fig. 6
From: Tumor microenvironment defines the invasive phenotype of AIP-mutation-positive pituitary tumors
Loss of AIP increases macrophage infiltrates in the Aip-knockout mice. Reticulin staining of wild type (WT) and homozygote knockout (AipFlox/Flox;Hesx1Cre/+) pituitary tissue showing disrupted reticulin network in the knockout animal. The bar graphs show the increased number of macrophages in Aip-knockout mice compared to the wild type. Representative images of macrophage infiltration in wild type and homozygote Aip-knockout mice as determined by F4/80 staining and quantified as the percentage of F4/80+ cells. Representative immunostaining with F4/80 mouse macrophage marker (data from n = 4 mice/genotype). Student’s t-test, *P < 0.05. Scale bar = 50 µm
