Table 1 Forty-seven known EMT-related genes in AIPpos somatotroph adenomas
From: Tumor microenvironment defines the invasive phenotype of AIP-mutation-positive pituitary tumors
Symbol | Entrez gene name | Affymetrix | Fold change |
|---|---|---|---|
ADAM17 | ADAM metallopeptidase domain 17 | 205746_s_at | 2.32 |
AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 242876_at | −2.92 |
APC | adenomatous polyposis coli | 203527_s_at | 2.80 |
BRAF | B-Raf proto-oncogene, serine/threonine kinase | 206044_s_at | −3.90 |
CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 201131_s_at | −27.00 |
CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 203440_at | −17.74 |
CLDN3 | claudin 3 | 203954_x_at | −3.14 |
CTNNB1 | catenin (cadherin-associated protein), beta-1, 88 kDa | 223679_at | −4.07 |
EGFR | epidermal growth factor receptor | 224999_at | −5.65 |
EPCAM | epithelial cell adhesion molecule | 201839_s_at | −2.42 |
ESRP1 | epithelial splicing regulatory protein 1 | 225846_at | −32.31 |
ESRP2 | epithelial splicing regulatory protein 2 | 219395_at | −5.92 |
FGF13 | fibroblast growth factor 13 | 205110_s_at | −7.93 |
FGFR1 | fibroblast growth factor receptor 1 | 222164_at | −4.63 |
FGFR2 | fibroblast growth factor receptor 2 | 203638_s_at | −4.64 |
FGFR3 | fibroblast growth factor receptor 3 | 204379_s_at | −9.55 |
FZD3 | frizzled class receptor 3 | 239082_at | −7.35 |
FZD5 | frizzled class receptor 5 | 221245_s_at | −3.71 |
FZD7 | frizzled class receptor 7 | 203706_s_at | −15.41 |
GSK3B | glycogen synthase kinase 3 beta | 226183_at | 2.89 |
HGF | hepatocyte growth factor (hepapoietin A; scatter factor) | 209960_at | −4.20 |
HRAS | Harvey rat sarcoma viral oncogene homolog | 212983_at | −2.11 |
JAG2 | jagged 2 | 32137_at | −2.97 |
JAK1 | Janus kinase 1 | 239695_at | −4.41 |
LEF1 | lymphoid enhancer-binding factor 1 | 221558_s_at | 3.57 |
LOX | lysyl oxidase | 215446_s_at | 2.76 |
MAP2K5 | mitogen-activated protein kinase kinase 5 | 204756_at | 2.01 |
MMP2 | matrix metallopeptidase 2 (gelatinase A, 72 kDa gelatinase, 72 kDa type IV collagenase) | 201069_at | 4.95 |
MMP9 | matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase) | 203936_s_at | 2.82 |
NOTCH2 | notch 2 | 202443_x_at | −4.95 |
PERP | PERP, TP53 apoptosis effector | 222392_x_at | −3.73 |
PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 241905_at | −7.36 |
PIK3C3 | phosphatidylinositol 3-kinase, catalytic subunit type 3 | 232086_at | 3.85 |
PIK3CB | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta | 217620_s_at | −2.41 |
PIK3CG | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma | 239294_at | 4.24 |
PSENEN | presenilin enhancer gamma secretase subunit | 218302_at | 2.92 |
RELA | v-rel avian reticuloendotheliosis viral oncogene homolog A | 201783_s_at | –2.10 |
RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 212589_at | –4.12 |
SMAD2 | SMAD family member 2 | 203076_s_at | 2.50 |
SMAD3 | SMAD family member 3 | 218284_at | –4.13 |
TCF4 | transcription factor 4 | 212385_at | 2.92 |
TCF7L1 | transcription factor 7-like 1 (T cell specific, HMG-box) | 221016_s_at | −2.41 |
TGFB2 | transforming growth factor, beta 2 | 209909_s_at | 8.74 |
TWIST1 | twist family bHLH transcription factor 1 | 213943_at | −4.84 |
WNT4 | wingless-type MMTV integration site family, member 4 | 208606_s_at | 7.04 |
WNT5A | wingless-type MMTV integration site family, member 5A | 213425_at | −4.70 |
ZEB1 | zinc-finger E-box binding homeobox 1 | 210875_s_at | 3.64 |
