Table 1 High-throughput screen identifying small molecule compounds that work in combination with CX-4945 to decrease MB growth

From: Casein kinase 2 inhibition sensitizes medulloblastoma to temozolomide

Compounds

Compound alone (% inhibition)

Compound + CX-4945 (% inhibition)

Activity

CX-4945

51.4

N/A

Inhibitor

Temozolomidea

48.1

74.3

Inhibitor

Raltitrexed

47.2

70.2

Inhibitor

Flubendazolea

61.4

68.1

Inhibitor

Ptersotilbene

22.0

59.4

Weak inhibitor

Itavastatin Ca

20.5

57.9

Weak inhibitor

  1. Individual treatments were compared to the combinatorial treatments of CX-4945 and the compound
  2. aCompound identified as an inhibitor again in duplicate screen