Fig. 7
Clinical evaluation of NEDD8 and CDKN1B/p27. a Overview of immunohistochemistry analysis for NEDD8 and p27 in 43 primary SI-NETs is shown. b–d Photomicrographs exemplifying diverse cytoplasmic and nuclear intensity of NEDD8 and p27 immunoreactivity in SI-NETs. b Case IHC-7 demonstrating strong cytoplasmic and nuclear NEDD8 (3+) and weak cytoplasmic and nuclear p27 (1+) staining, respectively. c Case IHC-18 exhibiting weak NEDD8 (1+) and strong p27 immunoreactivity. d Case IHC-5 with strong staining (3+) for both proteins. Cytoplasmic and nuclear staining were intimately associated and therefore scored conjoined. Membranous staining patterns were not observed. All photomicrographs are magnified ×100
