Fig. 1 | Oncogene

Fig. 1

From: The Epstein–Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization

Fig. 1

EBV carriage is associated with the accumulation of 8-oxodG. a Pairs of EBV-negative and -positive B-cell lymphoma lines were subjected to immunofluorescence staining with antibody against 8-oxodG (green) and the nuclei were stained with DAPI (blue). Representative micrographs illustrating the expression of 8-oxodG in the BJAB and BL41 cell pairs. b Quantification of 8-oxodG specific fluorescence in three independent experiments. Relative FL intensity is the ratio between FL intensity in EBV positive and negative cells. c 8-oxodG fluorescence was assayed in pairs of EBV-negative and -positive epithelial cell lines. Representative micrographs illustrating the expression of 8-oxodG (red). The nuclei were stained with DAPI (blue). d Quantification of the 8-oxodG specific fluorescence in three independent experiments. Significance was calculated using Student T-test, *P< 0.05, **P< 0.01

Back to article page