Table 1 The chromatin states and functions of FFL signatures
C1-FFLs in K562 | Chromatin state of genes | Functions | ||||
|---|---|---|---|---|---|---|
Top TF | Inter-TF | Target | Top TF | Inter-TF | Target | |
HCFC1 | NFYA | ABL1 | Active promoter | Active promoter | Active promoter | Mitotic nuclear division |
THAP1 | USF1 | BRCA2 | Active promoter | Active promoter | Active promoter | Regulation of cytokinesis |
ZNF263 | USF1 | UBA52 | Active promoter | Active promoter | Transcriptional elongation | G1/S transition of mitotic cell cycle |
MYC | ATF1 | UBA52 | Active promoter | Active promoter | Transcriptional elongation | G1/S transition of mitotic cell cycle |
YY1 | EGR1 | INO80C | Weak promoter | Active promoter | Weak transcribed | DNA recombination |
ELK1 | EGR1 | CCT4 | Transcriptional transition | Active promoter | Strong enhancer | Positive regulation of telomere maintenance |
