Fig. 2: PIERCE1 expression and its tumorigenic function in KRAS-mutant lung cancer. | Oncogene

Fig. 2: PIERCE1 expression and its tumorigenic function in KRAS-mutant lung cancer.

From: Impaired AKT signaling and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer

Fig. 2: PIERCE1 expression and its tumorigenic function in KRAS-mutant lung cancer.The alternative text for this image may have been generated using AI.

Relative expression of PIERCE1 transcripts in large-cell carcinoma (Large) and lung adenocarcinoma (LA) from the Hou lung database (a), squamous-cell carcinoma (SCC) and LA from TCGA database (b), KRAS wild type (WT) and mutant type (Mut) of LA from Bild lung (c) and Ding lung (d) databases, and WT and mutant KRAS lung cancer, and normal lung cell lines (e). KRAS genotype was indicated on the bottom of samples and cell line names. For panel a–d, Oncomine database of Hou, TCGA, Bild, and Ding were analyzed. Colony forming assays of NIH3T3 cells 14 days after transfection for overexpression (f) or knockdown (g) of PIERCE1. Colonies were formed by overexpression of mutant HRAS (HRASV12). Representative images and average numbers of colonies were shown in the upper and the lower panel, respectively. Error bars are ±SD *P < 0.05; **P < 0.01; ***P < 0.0001.

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