Fig. 4: Active AKT rescues PIERCE1 KD-mediated cell growth retardation. | Oncogene

Fig. 4: Active AKT rescues PIERCE1 KD-mediated cell growth retardation.

From: Impaired AKT signaling and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer

Fig. 4: Active AKT rescues PIERCE1 KD-mediated cell growth retardation.The alternative text for this image may have been generated using AI.

Western blot analyses for AKT and ACTIN (a) and the growth rates (b) of control (shCTL), PIERCE1 KD (shP#1 and shP#3), and PIERCE1 KD with overexpression of myristoylated AKT (shP#1+AKT and shP#3+AKT) cell lines in A549 cell line. A representative image of xenograft tumors of cell lines 35 days after s.c. injection into nude mice (c) and their growth rates (d). White bar indicates 1 cm. Error bars represent ±SD. Statistical analysis was performed using one-way ANOVA for b and d. *P < 0.05; **P < 0.01.

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