Fig. 3: Gal2 deficiency attenuated DSS-induced acute colitis. | Oncogene

Fig. 3: Gal2 deficiency attenuated DSS-induced acute colitis.

From: Genome-wide CRISPR screen identifies LGALS2 as an oxidative stress-responsive gene with an inhibitory function on colon tumor growth

Fig. 3

A The body mass change over the 8-day course of DSS (5%) treatment and 4-day recovery period (regular drinking water). WT and Gal2-KO mice without DSS treatment served as controls. B The DAI of the WT and Gal2-KO mice over the course of DSS treatment. C The colon lengths of WT and Gal2-KO mice after DSS treatment. D Kaplan–Meier survival curve of age-matched WT and Gal2-KO mice following treatment with DSS. E Representative H&E-stained colon sections from WT and Gal2-KO mice with or without DSS treatment. Scale bar, 100 μm. F The inflammation/lesion score was blindly assessed by a board-certified pathologist. *p < 0.05, **p < 0.01, ***p < 0.001 (t-test for A, B, F; one-way ANOVA for C).

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