Fig. 3: Overexpression of LINC00261 suppresses pancreatic tumor growth and metabolic levels in vivo. | Oncogene

Fig. 3: Overexpression of LINC00261 suppresses pancreatic tumor growth and metabolic levels in vivo.

From: Epigenetic silencing of LncRNA LINC00261 promotes c-myc-mediated aerobic glycolysis by regulating miR-222-3p/HIPK2/ERK axis and sequestering IGF2BP1

Fig. 3

A Tumors were generated in nude mice using Panc1 and Mia-PaCa2 cells expressing LINC00261 or empty vector. B The tumor volume was calculated every 4 days from the initial injection. C The tumor weight was measured after resection. D IHC analysis using sliced tumor tissue derived from Panc1 cells incubated with Ki-67 and TUNEL antibodies. E Pet-CT imaging detecting the metabolic level of pancreatic tumors derived from Panc1 cells. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.

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