Fig. 8: Proposed model demonstrating the epigenetic modification and functional significance of LINC00261 in the progression of pancreatic cancer. | Oncogene

Fig. 8: Proposed model demonstrating the epigenetic modification and functional significance of LINC00261 in the progression of pancreatic cancer.

From: Epigenetic silencing of LncRNA LINC00261 promotes c-myc-mediated aerobic glycolysis by regulating miR-222-3p/HIPK2/ERK axis and sequestering IGF2BP1

Fig. 8

The expression of LINC00261 is repressed by DNA methylation and EZH2-mediated H3K27 trimethylation. LINC00261 exerts its tumor suppressive function by regulating miR-222-3p/HIPK2/ERK axis and sequestering IGF2BP1.

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