Table 1 Summary of current research neural remodeling in PDAC and CCA.
References | Samples | Neural marker | Key results | Cancer types |
|---|---|---|---|---|
Iwasaki et al. [73] | 256 | GAP-43 | Neural hypertrophy and nerve numbers are decreased; | Pancreatic carcinoma |
Fisher et al. [105] | 58 | Presence of PNI was associated with a reduction of OS | Cholangiocarcinoma | |
Chatterjee et al. [17] | 212 | Presence of PNI was directly correlated with tumor size, margin status, lymph node metastasis, pathologic tumor and AJCC stages, and shorter DFS and OS | Pancreatic carcinoma | |
Lenz et al. [106] | 177 | 80.3% of PDAC detected PNI; Neural remodeling progress can be a reason of pancreatic neuropathy; | Pancreatic carcinoma | |
Shimada et al. [99] | 153 | Degree of PNI was directly related to lymph node metastases, surgical margin and tumor sides size, and inversely associated with DFS | Pancreatic carcinoma | |
Ceyhan et al. [107] | 97 | GAP-43 NGF PGP9.5 Artemin | There were enlarged nerves and dense neural networks in pancreatic carcinoma slides; Neurotrophic characteristics GAP-43, NGF and Artemin are increased in pancreatic carcinoma and have close relevancy with intrapancreatic neuropathy. | Pancreatic carcinoma |
Ceyhan et al. [103] | 149 | GAP-43 PGP9.5 NGF | Neural hypertrophy, neural density increased; Neuropathic alteration was not correlated with survival in pancreatic carcinoma, these changes include neural thickness, hypertrophy, density. Only the severity of pain significantly affects survival. | Pancreatic carcinoma |
Ceyhan et al. [103] | 564 | GAP-43 | Neural density is increased and nerves are enlarged in pancreatic carcinoma, the severity of PNI was linked to neuropathic changes and pain. | Pancreatic carcinoma |
Shirai et al. [104] | 59 | 80% of CCA samples detected PNI; 5 years survival rates of patients with or without PNI were 17% and 70%, respectively. | Cholangiocarcinoma |
