Fig. 3: Overexpression of LNC CRYBG3 promotes tumorigenesis and metastasis by targeting BUB3. | Oncogene

Fig. 3: Overexpression of LNC CRYBG3 promotes tumorigenesis and metastasis by targeting BUB3.

From: RETRACTED ARTICLE: The long noncoding RNA CRYBG3 induces aneuploidy by interfering with spindle assembly checkpoint via direct binding with Bub3

Fig. 3: Overexpression of LNC CRYBG3 promotes tumorigenesis and metastasis by targeting BUB3.The alternative text for this image may have been generated using AI.

A Top 20 enrichment KEGG pathways of the protein expression profile obtained with global protein mass spectrum assay in LNC CRYBG3 overexpressing A549 cells lines. B The heat map of total differentially expressed cell cycle-related proteins in A549 cells overexpressing LNC CRYBG3. C Representative protein expressions that were upregulated in B were validated using western blot including Cyclin B1 and Cyclin D1. D Expression of Bub3 in primary tumors (n = 515) compared to normal tissues (n = 59) in TCGA database. E Overall survival curves of patients with NSCLC tumors of different Bub3 expression levels (n = 215). The expressions of Bub3 in NSCLC tissues were analyzed using the Cancer Genome Atlas data set. F Correlation between Bub3 expression level and individual NSCLC stages (n = 574). G Bub3 expression level visualized by immunohistology. **p < 0.01.

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