Fig. 7: A schematic illustration of the effect of CHIR99021 on the level of SOX10 protein. | Oncogene

Fig. 7: A schematic illustration of the effect of CHIR99021 on the level of SOX10 protein.

From: Temporal activation of WNT/β-catenin signaling is sufficient to inhibit SOX10 expression and block melanoma growth

Fig. 7

CHIR99021 is a small chemical compound that competes with ATP for the binding site in GSK3α/β kinase and thereby inhibits GSK3α/β, leading to the activation of WNT signaling. SOX10 protein levels are reduced following pharmacologic, acute β-catenin stabilization, and this is mediated via proteasomal degradation.

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