Fig. 4: Representation of the protein-coding sequences and major functional domains in DNA repairome genes in PCa samples.
From: Somatic mutations in the DNA repairome in prostate cancers in African Americans and Caucasians
a Location of mutations and protein domains encoded by the top mutated genes ATR, BRCA1, NEIL3, ERCC6, and EXO1 in African American PCa samples. b Location of mutations and protein domains encoded by the op mutated genes BRCA1, NEIL3, EXO1, ERCC6, and POLQ in Caucasian PCa samples, determined using cBioPortal/mutation-mapper. Protein domains are distinguished by color. On the graph of each gene, the y axis represents the number of mutations identified and the x axis reflects the number of amino acid residues. Somatic mutations are shown in circles; missense mutations are shown in green-circle, silent mutations are shown in purple-circle, and truncating mutations are shown in black-circle. Helic helicase, H2TH helix-2turn-helix domain, ZF-GRF zinc finger GRF domain, BRCT BRCA1.
