Table 2 Distribution of recurrent somatic substitutions in prostate tumors in African American men (n = 19).
From: Somatic mutations in the DNA repairome in prostate cancers in African Americans and Caucasians
Variant | DNA Repair Pathways | Incidence | Frequency (%) |
|---|---|---|---|
ERCC6 | NER | ||
p.M1097V | – | 4 | 21 |
p.G399* | – | 5 | 26 |
p.L45L | – | 4 | 21 |
XPC | – | ||
p.Q939K | – | 7 | 36 |
p.A499V | – | 4 | 21 |
NEIL3 | BER | ||
p.P117R | – | 3 | 15 |
p.R381R | – | 4 | 21 |
p.Q471H | – | 3 | 15 |
EXO1 | MMR | ||
p.E589K | – | 8 | 42 |
p.H354R | – | 4 | 21 |
p.V458M | – | 6 | 31 |
ATR | – | ||
p.M211T | – | 4 | 21 |
p.G592G | – | 4 | 21 |
ATM | – | ||
p.D1853N | – | 4 | 21 |
TMPRSS2 | |||
p.V160M | 4 | 21 | |
p.T75* | 4 | 21 | |
AR | |||
p.E213* | 3 | 15% |
