Fig. 7: Overall schematic presentation.
From: AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis
When Hippo is activated, it promotes YAP1 to degrade ubiquitination in the cytoplasm. In GC cells, abundant AMOTL1 protects YAP1, reduces its phosphorylation, and promotes its nuclear translocation. In the nucleus, YAP1 binds with transcriptional factor TEAD to activate the downstream CTGF expression and thus to drive gastric carcinogenesis. The administration of small-molecule VP blocks the interaction of AMOTL1 and YAP1 and quenches their oncogenic properties.
