Fig. 1: The cellular heterogeneity of the glioblastoma micro-environment.
From: Breaking through the glioblastoma micro-environment via extracellular vesicles
Constant multi-directional communication between glioblastoma cells and normal stromal cells such as endothelial cells or astrocytes allows the tumour to hijack its surrounding micro-environment, thus triggering a tumour supportive phenotype. Extracellular vesicles have been recently described as being directly involved in such crosstalk, along with diffusible cytokines and growth factors.
