Fig. 2: Glioblastoma stem cell-derived extracellular vesicles can stimulate neo-angiogenesis via miR-26a (Adapted from Wang et al. [25]). | Oncogene

Fig. 2: Glioblastoma stem cell-derived extracellular vesicles can stimulate neo-angiogenesis via miR-26a (Adapted from Wang et al. [25]).

From: Breaking through the glioblastoma micro-environment via extracellular vesicles

Fig. 2

Extracellular vesicles derived from glioblastoma stem cells transfer miR-26a to endothelial cells, consequently inhibiting phosphatase and tensin homolog (PTEN) and promoting the activation of the PI3K/AKT pathway. Such activation upregulates the VEGF expression with consecutive promotion of the neo-angiogenesis process.

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