Fig. 7: Schematic diagram of EphA2–YES1–ANXA2 pathway in GC growth and progression. | Oncogene

Fig. 7: Schematic diagram of EphA2–YES1–ANXA2 pathway in GC growth and progression.

From: EphA2–YES1–ANXA2 pathway promotes gastric cancer progression and metastasis

Fig. 7: Schematic diagram of EphA2–YES1–ANXA2 pathway in GC growth and progression.The alternative text for this image may have been generated using AI.

EphA2 interacts with YES1 and phosphorylates YES1 at Tyr426 site that results in YES1 activation. Activated YES1 interacts with ANXA2 andphosphorylates ANXA2 at Tyr24 site that induces ANXA2 activation and increases ANXA2 nuclear distribution, leading to activation of the tumorpromoting transcription factors (such as Myc, Stat3, Stat6) that promotes GC invasion and metastasis.

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