Fig. 7: RNF141 regulates cell proliferation and apoptosis by KRAS.
From: RNF141 interacts with KRAS to promote colorectal cancer progression
A The effects of RNF141 knockdown on protein levels of MEK, p-MEK, ERK, p-ERK was assessed by Western blot. B, C Protein levels of PCNA, Cleaved caspase-3, Cleaved PARP, KRAS, and RNF141 in HCT116 (B) and HT29 (C) cells co-transfected with indicated siRNA and lentivirus were validated by Western blot. D, E Cell proliferation of HCT116, SW480, DLD-1 cells co-transfected with indicated siRNA and lentivirus was examined by CCK-8 assay (D) and plate colony formation assay (E). Data were mean ± SD from three independent experiments, each performed in triplicate. **P < 0.01, ***P < 0.001.
