Fig. 2: LINC00662 promotes OC cell proliferation in vitro and in vivo.
From: HNRNPH1-stabilized LINC00662 promotes ovarian cancer progression by activating the GRP78/p38 pathway
A CCK-8 cell proliferation assays of A2780 and OVCA433 cells transfected with LINC00662 siRNAs or scrambled controls. B Cell proliferation assays of SK-OV-3 and OVCAR-3 cells infected with lentivirus expressing LINC00662 or control lentivirus. C Colony formation assay of A2780 and OVCA433 cells transfected with LINC00662 siRNAs or scrambled controls. D Colony formation assay of SK-OV-3 and OVCAR-3 cells infected with lentivirus expressing LINC00662 or control lentivirus. E Representative images of xenografts formed by subcutaneous injection of A2780 cells stably transfected with control or shRNA-mix into the right axilla of nude mice (n = 10 mice per group). F, G Growth curves and weights of tumors formed by stable A2780 cells infected with lentivirus for knockdown of LINC00662 or control lentivirus. H, I Immunohistochemical staining was conducted to compare proliferation indices via assessment of Ki‐67 expression. Data are shown as means ± SEMs. A two-tailed Student’s t-test was used for statistical analysis. *P < 0.05; **P < 0.01; ***P < 0.001. P < 0.05 was considered significant.
