Fig. 3: ZDHHC1 mediates p53 palmitoylation.
From: Cancer cells escape p53’s tumor suppression through ablation of ZDHHC1-mediated p53 palmitoylation
A Predicted cysteine residues on p53 susceptible to S-palmitoylation. B IP-ABE analysis of p53 palmitoylation in HONE1 and in 293T cells were treated with pirarubicin (THP). C IP-ABE analysis of p53 palmitoylation in H1299 cells when ectopically expressing p53WT or p53 harboring specific mutations. D IP-ABE analysis of p53 palmitoylation in H1299 cells when treated with palmitoylation inhibitor 2Brp or promoter PA. HAM hydroxylamine, 2Brp 2-bromopalmitate, PA Palmitic acid.
