Fig. 4: ZDHHC1 mediates p53 phosphorylation and nuclear translocation.
From: Cancer cells escape p53’s tumor suppression through ablation of ZDHHC1-mediated p53 palmitoylation
A Western blot analysis of the correlation between site-specific p53 mutations and p53 phosphorylation. B Quantification of the Western blot results in Fig. 4A. C Subcellular localization of ectopic p53WT in H1299 cells. D Subcellular localization of ectopic p53 with specific Cys substitutions in H1299 cells. E Subcellular localization of ZDHHC1 (top) or ZDHHC1-C164A (bottom) and p53 in HONE1 cells when treated with 2Brp or PA. Values represent mean ± SEM. *p < 0.05. ***p < 0.001. 2Brp 2-bromopalmitate, PA Palmitic acid.
