Fig. 6: RAC1 inhibitor affects ER enhancer function.
From: RAC1 plays an essential role in estrogen receptor alpha function in breast cancer cells
A Average binding profiles derived from ChIP-seq analyses for ER, RAC1, SRC-3, or RNA pol II in MCF-7 cells treated with vehicle control, 10 nM E2, 50 µM EHT 1864 or their combination for 45 min. The top 10,000 ER binding sites in the presence of E2 were selected for signal profiles of ER, SRC-3 and RNA pol II, while the top 1000 RAC1 sites were selected for RAC1 signal profiles. B The Venn diagrams of occupancy sites detected for ER, SRC-3 and RAC1 (q < 0.01) under the indicated treatments. C The average RNA pol II signal profiles for the indicated treatments at a group of E2-activated genes (left panel) and at a group of non ER target genes (right panel).
