Fig. 3: DEGS2 is involved in m6A-regulated carcinogenesis in CRC. | Oncogene

Fig. 3: DEGS2 is involved in m6A-regulated carcinogenesis in CRC.

From: M6A methylation of DEGS2, a key ceramide-synthesizing enzyme, is involved in colorectal cancer progression through ceramide synthesis

Fig. 3: DEGS2 is involved in m6A-regulated carcinogenesis in CRC.The alternative text for this image may have been generated using AI.

a Overlapping genes with twofold expression changes in the RNA-seq and m6A-seq analyses. b The relative expression of DEGS2 in colon (left) and rectal (right) cancer tissues and their corresponding adjacent normal tissues based on data available from the TCGA database. c, d Expression of DEGS2 in paired human CRC tissues and adjacent normal mucosa tissues (n = 17) by RT-qPCR and WB. e Images of IHC staining of DEGS2 in 86 CRC tissues and 78 adjacent normal tissues and quantification analysis of DEGS2 in CRC tissues compared with the control tissues. f Representative images of IHC staining of DEGS2 and PDL1 and hematoxylin-eosin (HE) staining. The high (upper) and low (lower) expression levels of DEGS2 were evaluated semiquantitatively by recording the staining intensity (high score: 27–90; low score: 0–27). g Chi-square analysis of CD8-, PD1-, and PDL1-positive expression rate in 86 CRC tissues and 78 adjacent normal tissues.

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