Table 1 Mammalian DNA polymerases.
From: Unravelling roles of error-prone DNA polymerases in shaping cancer genomes
Polymerase | Official symbol | GeneID | Family | Canonical pathway assignment |
|---|---|---|---|---|
Pol ε | POLE | 5426 | B | Replication (leading strand) |
Pol δ (POLD1, POLD2, POLD3, POLD4) | POLD1, POLD2, POLD3, POLD4 | 5424, 5425, 10714, 57804 | B | Replication (lagging strand) |
Pol α | POLA1 | 5422 | B | Replication (RNA primer during DNA replication) |
Pol ζ (REV3L, REV7 (aka MAD2L2), POLD2, POLD3) | REV3L, MAD2L2 | 5980, 10459 | B | TLS extension |
Pol γ | POLG | 5428 | A | Replication (mitochondrial) |
Pol θ | POLQ | 10721 | A | TMEJ |
Pol ν | POLN | 353497 | A | End processing? |
Pol β | POLB | 5423 | X | BER |
Pol λ | POLL | 27343 | X | BER |
Pol μ | POLM | 27434 | X | NHEJ |
TdT | DNTT | 1791 | X | NHEJ |
Pol η | POLH | 5429 | Y | TLS |
Pol ι | POLI | 11201 | Y | TLS |
Pol κ | POLK | 51426 | Y | TLS |
REV1 | REV1 | 51455 | Y | TLS |
Telomerase | TERT | 7015 | RT | End replication (telomere) |
PrimPol | PRIMPOL | 201973 | PrimPol | ? |
