Fig. 2: Propranolol treatment reduces tumor angiogenesis. | Oncogene

Fig. 2: Propranolol treatment reduces tumor angiogenesis.

From: Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment

Fig. 2

A–C Quantification of angiogenic marker Vegfa gene expression in MCA205 (A), MC38 (B), and SVR (C) tumors from control mice and propranolol (PRO) treated mice by qRT-PCR (n = 5). D–F Quantification of Kdr gene expression in MCA205 (D), MC38 (E), and SVR (F) tumors from control mice and propranolol (PRO) treated mice by qRT-PCR (n = 5). G Representative CD34 (brown) IHC staining of MCA205 tumor tissue from control mice or propranolol treated mice; hematoxylin counterstain; scale bar 100 µm (left panels), and 50 µm (right panels). H Dot plot showing quantification of CD34 staining by percentages of DAB + area in 9 control mice and 11 propranolol treated mice. *p < 0.05, **p < 0.01, n.s. Not significant, according to multiple t test with Bonferroni correction. Mean ± SEM are depicted.

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