Fig. 3: Gastrokine expression during pancreatic inflammation, in vitro in acinar cells and its detection in pancreatic juice. | Oncogene

Fig. 3: Gastrokine expression during pancreatic inflammation, in vitro in acinar cells and its detection in pancreatic juice.

From: De novo expression of gastrokines in pancreatic precursor lesions impede the development of pancreatic cancer

Fig. 3

A Infiltrating inflammatory cells (*) around the PanIN lesions in KC mice. Immunohistochemical GKN1 and GKN2 positivity, while the inflammatory cells are negative (scale bars 50 µm). B H&E, GKN1, and GKN2 staining in C57BL/6 mice (scale bar 100 µm) and in different models of pancreatic inflammation (scale bars 50 µm). The histological images of cerulein treatment represents the chronic treatment regimen. C Light microscopy photos of isolated acinar cells embedded in collagen matrix from wt and KC mice at day 0 and day 4. Gkn1 and Gkn2 gene expression of KC acinar cells compared to untreated wild type acinar cells. D Gkn1 and Gkn2 protein expression on western blot in serum of 9 months old wild type and KC mice.

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