Fig. 4: Early lesions and tumor incidence. | Oncogene

Fig. 4: Early lesions and tumor incidence.

From: De novo expression of gastrokines in pancreatic precursor lesions impede the development of pancreatic cancer

Fig. 4

A Representative H&E stainings showing 3 and 9 month old pancreata from KC, Gkn1KC and Gkn2KC mice. Lesion occupied area is framed in red (scale bars 200 µm). Right panel shows area quantification of occupying lesions at 3, 6, and 9 months time points (one-way ANOVA). B Time dependent probability of malignant occurrence curve displays all animals presenting malignancy. Mice were sacrificed when termination criteria were met or 9 month’s time point was reached; (Gehan–Breslow–Wilcoxon analysis). Right panel shows % of mice harboring a tumor KC = 21%, Gkn1KC = 44% and Gkn2 = 39%. * including Gkn1 heterozygous-KC.

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