Fig. 5: Apoptosis, senescence and proliferation related changes in Gkn1KC and Gkn2KC mice. | Oncogene

Fig. 5: Apoptosis, senescence and proliferation related changes in Gkn1KC and Gkn2KC mice.

From: De novo expression of gastrokines in pancreatic precursor lesions impede the development of pancreatic cancer

Fig. 5

A Cleaved caspase-3 quantification displayed as positive cells/image field for KC and Gkn1KC at 3 and 9 months of age with representative IHC images. B Western blot at 3 months, indicating differential regulation of extrinsic apoptotic pathway in Gkn1KC compared to KC pancreatic tissue. Densitometric analysis of FAS (left graph) and Cleaved Caspase-8/ Total Caspase-8. C γH2AX quantification shown as positive cells/ image field for KC and Gkn1KC mice at 3 and 9 months of age with representative IHC images. D Amount of Ki-67 positive cells per PanIN in Gkn2KC mice at 3 and 9 months (scale bars 100 µm) (one-way ANOVA).

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