Fig. 1: LIN28 expression in human BCs and cells. | Oncogene

Fig. 1: LIN28 expression in human BCs and cells.

From: RNA-binding protein complex LIN28/MSI2 enhances cancer stem cell-like properties by modulating Hippo-YAP1 signaling and independently of Let-7

Fig. 1

A, B LIN28A protein expression levels in 6 normal and 82 BC tissues (with different subtypes) were detected by IHC and evaluated according to the signal scores. IHC staining score ≤ 6 was regarded as low expression and a score > 6 was defined as high expression. C Quantitation of LIN28A expression level in 82 BC tissues with different subtypes according to the IHC scores. D Representative images indicated the expression of LIN28A in 6 normal tissues and 82 BC tissues detected with IHC. Scale bars: 100 μm. E Representative images indicated the expression of LIN28A in 82 BC tissues with different TNM stages detected with IHC. Scale bars: 100 μm. F Quantitation of LIN28A expression level in 82 BC tissues with different TNM stages according to the IHC scores. G WB analyses of total proteins from patient tumor tissues with different subtypes using the indicated antibodies. H Quantitation of LIN28A expression level by WB analyses in different subtypes of BC tissues. I WB analyses of total proteins from the 293T cells, MCF-10A cells, and different subtypes of BC cells using the indicated antibodies. J IHC analyses of LIN28A protein expression in MDA-MB-231 or CAL51 cell-derived xenograft tissues. Scale bars: 100 μm.

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