Fig. 3: LNMAS inhibits cervical cancer cells metastasis and tumor growth in vivo. | Oncogene

Fig. 3: LNMAS inhibits cervical cancer cells metastasis and tumor growth in vivo.

From: Downregulation of LNMAS orchestrates partial EMT and immune escape from macrophage phagocytosis to promote lymph node metastasis of cervical cancer

Fig. 3: LNMAS inhibits cervical cancer cells metastasis and tumor growth in vivo.

A Representative images of popliteal LNs in the indicated mice group. B Representative images of HE and IHC staining with anti-pan-keratin antibody in the indicated mice group. C The popliteal LN metastasis rate in the indicated mice group. D Representative IHC images of peritumoral (n = 8) and intratumoral (n = 8) lymphatic vessels stained by anti-LYVE-1 in the primary tumors resected from footpads in the indicated mice group. E Representative HE images of lung metastasis in the indicated mice group (n = 4). F Representative images of subcutaneous xenografts in the indicated mice group. G Tumor growth curves (n = 4) and the weight of tumors upon sacrifice in the indicated mice group (n = 4). Statistical significance was assessed by Student’s t test. Data are presented as mean ± SD, *P < 0.05, **P < 0.01.

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