Fig. 7: ATR inhibition significantly decreases tumour burden and prolongs survival in JEG3R mouse models.
From: ATR and CDK4/6 inhibition target the growth of methotrexate-resistant choriocarcinoma
A–B JEG3R cells were injected at the uterine horn of nude mice. Mice received either Vehicle-only (VO), VX-970 (VX-60mg/kg) and/or Methotrexate (MTX-1mg/kg). A Kaplan–Meier curve (upper panel) and corresponding median survival and associated statistics (lower panel). B Uterine weight was determined at end-point. Statistics: (A–B) ANOVA. ***p < 0.005, **p < 0.01, *p < 0.05, ns not significant.
