Fig. 2: Vav proteins regulate skin stem cell-dependent responses.
From: The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function
A Representative images of the dorsal skin from mice of indicated genotypes after being subjected to a wound healing experiment. Scale bar, 3 mm (n = 5). B Plots showing the wound size (left) and prevalence (right) in mice of indicated genotypes according to the data obtained in A. P < 0.001 (two-way ANOVA and Sidak’s multiple comparisons test (left), Chi-squared test (right), n as in A). C Representative images of the dorsal skin from mice of indicated genotypes 6 days after being subjected to wound healing experiments. Scale bar, 4 mm (n = 5). D Plots showing the wound size (left) and prevalence (right) in mice of indicated genotypes according to data obtained in C. P < 0.001 (two-way ANOVA and Sidak’s multiple comparisons test (left), Chi-squared test (right), n as in C). E, G Representative images of the hair regrowth in depilated mice of indicated genotypes. Scale bar, 2 mm. F, H Quantitation of hair regeneration kinetics obtained in E (F) and G (H). P < 0.001 (two-way ANOVA and Sidak’s multiple comparisons test); n = 6. In B, D, F and H, data represent mean ± SEM.
