Fig. 3: HRD status of 71 breast cancers as defined by different HRD tests. | Oncogene

Fig. 3: HRD status of 71 breast cancers as defined by different HRD tests.

From: Functional RECAP (REpair CAPacity) assay identifies homologous recombination deficiency undetected by DNA-based BRCAness tests

Fig. 3: HRD status of 71 breast cancers as defined by different HRD tests.

A, B Venn-diagrams showing overlap among RECAP, BRCA1/2-like classifier and CHORD test outcomes and comparisons of RECAP test and BRCA1/2-like classifier and CHORD test. A HRD/HRi tumors and (B) HRP tumors as identified by one or multiple HRD tests. The numbers in the circles correspond to the number of HRD/HRi tumors (A) or HRP tumors (B) identified by that test. C HRD status of BRCA inactivated cases per HRD test. Green = HRP, orange = HRi, red = HRD. 1 = BRCA1 mutation, 2 = BRCA2 mutation, M = BRCA1 methylation, V = BRCA1/2 VUS, N = normal BRCA status. *mono-allelic BRCA2 inactivation.

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