Fig. 7: A schematic model summarizing the oncogenic roles of TET1 in thyroid cancer under hypoxia.
From: Hypoxia switches TET1 from being tumor-suppressive to oncogenic
Briefly, under hypoxia, TET1 promotes CK2B expression by stabilizing the transcriptional active complex of HIF1α/p300. In turn, CK2β facilitates the integration and enzyme maximization of CK2 to fully activate AKT signaling via phosphorylation and inactivation of PTEN. Activated AKT cascade prevents the FBW7-mediated K48-linked ubiquitination and degradation of HIF1α, thereby forming a positive CK2/AKT/GSK3β/HIF1α feedback loop to accelerate tumor progression.
