Table 1 Hematopoietic tumor invasion in hTS/Ink4a/Arf −/− vs. Ink4a/Arf −/−.

From: TYMS promotes genomic instability and tumor progression in Ink4a/Arf null background

Tumor type

Ink4a/Arf −/−

hTS/Ink4a/Arf −/−

number/Total mice

%

number/Total mice

%

Histiocytic Sarcoma

 Lesion restricted in 1–3 organsa

6/8

75

4/26

15

 Lesion invasion to in 4–9 organsb

2/8

25

22/26

85**

Lymphoma

 Lesion restricted in 1–3 organsa

29/38

76

29/53

55

 Lesion invasion to in 4–9 organsb

9/38

24

24/53

45*

  1. aLymph node, spleen and liver;
  2. bLymph node, spleen, liver, kidney, bone marrow, pancreas, stomach, lung, small intestine, skeletal muscle, brain, spine, thymus, heart, ovary, uterus, testes, gallbladder, soft tissue, adrenal gland and skin.
  3. **P < 0.01, *P < 0.05.
Back to article page