Table 2 Tumor incidence in Ink4a/Arf −/− and hTS/Ink4a/Arf −/− mice.

From: TYMS promotes genomic instability and tumor progression in Ink4a/Arf null background

Tumor type

Ink4a/Arf −/− (n = 52)

hTS/Ink4a/Arf −/− (n = 84)

mice with tumor/total mice

%

mice with tumor/total mice

%

Histiocytic Sarcoma

8/52

15.4

26/84

31.0*

 Male

2/24

8.3

16/38

42.1**

 Female

6/28

21.4

10/46

21.7

Lymphoma

38/52

73.1

53/84

63.1

 Male

17/24

71.8

20/38

52.6

 Female

21/28

75.0

33/46

71.7

Fibrosarcoma

10/52

19.2

16/84

19.0

 Male

8/24

33.3

9/38

23.7

 Female

2/28

7.1

7/46

15.2

Soft tissue sarcomaa and teratoma

0/52

0

6/84

7.14*

  1. aNon-fibrosarcoma with tumor mass bigger than 1g: liposarcoma (n = 1), rhabdomyosarcoma (n = 2), leiomyosarcoma (n = 1), endometrial stromal sarcoma (n = 1).
  2. *P < 0.05; **P < 0.005; ***P < 0.001.
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