Fig. 8: The clinical significance of the ALKBH5/HDAC4/HIF1α axis in pancreatic cancer. | Oncogene

Fig. 8: The clinical significance of the ALKBH5/HDAC4/HIF1α axis in pancreatic cancer.

From: m6A methylation regulates hypoxia-induced pancreatic cancer glycolytic metabolism through ALKBH5-HDAC4-HIF1α positive feedback loop

Fig. 8

A The expression levels of ALKBH5, HDAC4 and HIF1α were analyzed in PC (n = 179) and normal pancreas tissues (n = 171) using TCGA and GTEx data. B The expression correlation between ALKBH5, HDAC4 and HIF1α according to TCGA PC dataset. C Immunohistology staining of ALKBH5, HDAC4 and HIF1α expression in 22 PC specimens. Two representative cases are shown. D The percentages of specimens showing low or high HIF1α expression relative to the levels of ALKBH5 and HDAC4. E The mRNA levels of ALKBH5 were positively correlated with hypoxia-induced marker genes GLUT1, GLUT3, HK2 or LDHA according to TCGA and GTEx dataset. Similarly, there were positive correlations between HDAC4 and hypoxia-induced marker genes. *P < 0.05, **P < 0.01, ***P < 0.001 and ns not significant.

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